abstract：:TNF-alpha plays an important role in the development of secondary lymphoid tissues. Earlier studies showed that fibroblastic reticular cells express TNF-alpha receptor, suggesting that TNF-alpha may affect the development of FRCs. To test this, we analyzed the development and function of FRCs in wild-type or TNF-alpha...

journal_title：Cellular immunology

authors： Zhao L,Chen J,Liu L,Gao J,Guo B,Zhu B

更新日期：2015-02-01 00:00:00

abstract：:Nonenzymatic glycation of amino groups of DNA bases by reducing sugars can generate advanced glycation end products (AGEs). Cellular formation of AGEs under normal physiology is continuously scanned and removed by efficient system in the cells. However, excess formation and accumulation of AGEs may be cause or consequ...

journal_title：Cellular immunology

authors： Ashraf JM,Arfat MY,Arif Z,Ahmad J,Moinuddin,Alam K

更新日期：2015-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are aberrant in many human tumors which can be transferred to immune cells by tumor-derived exosomes. Dendritic cells (DCs) play an important role in activation of immune response. However, the effect of tumor-derived exosomes on toll-like receptor (TLR) in DCs remains unclear. We investigated the i...

journal_title：Cellular immunology

authors： Zhou M,Chen J,Zhou L,Chen W,Ding G,Cao L

更新日期：2014-11-01 00:00:00

abstract：:Over the last three decades it has become increasingly clear that monocytes, originally thought to have fixed, stereotypic responses to foreign stimuli, mediate exquisitely balanced protective and pathogenic roles in disease and immunity. This balance is crucial in core functional organs, such as the central nervous s...

journal_title：Cellular immunology

authors： Ashhurst TM,van Vreden C,Niewold P,King NJ

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Many CD95-expressing cells don't always undergo apoptosis after stimulation with CD95 ligation. The purpose of this paper is to investigate the role of expression of CD95 (Fas/Apo1) on inflammatory response in fibroblast-like synoviocytes (FLS) obtained from rheumatoid arthritis (RA) and to evaluate the role ...

journal_title：Cellular immunology

authors： Li X,Zhang Z,Peng A,He M,Xu J,Shen S,Zhuang J,Huang X

更新日期：2014-08-01 00:00:00

abstract：:Psoriasis is a common dermatosis mediated by T cells. This study investigated the correlation of Th22 cells and Tc22 cells with psoriasis. A total of 30 psoriasis patients and 11 age- and sex-matched healthy controls were recruited for this study. The proportions of circulating Th22 and Tc22 cells, expression of aryl ...

journal_title：Cellular immunology

authors： Luan L,Ding Y,Han S,Zhang Z,Liu X

更新日期：2014-08-01 00:00:00

abstract：:7 anterior gradient homolog 2 (AGR2)-inhibited different molecular mutual positive correlation network was constructed in lung adenocarcinoma compared with human normal adjacent tissues by 17 overlapping molecules of 358 GRNInfer and 19 Pearson (AGR2 CC⩽-0.25). Based on GO, KEGG, GenMAPP, BioCarta and disease database...

journal_title：Cellular immunology

authors： Huang J,Wang L,Jiang M,Chen Q,Jiang Z,Feng H

更新日期：2014-07-01 00:00:00

abstract：:The programmed death (PD)-1/PD-1 ligands (PD-Ls) pathway, is a new member of the B7/CD28 family, and consists of the PD-1 receptor and its ligands PD-L1 (B7-H1, CD274) and PD-L2 (B7-DC, CD273). Recently, it is reported that PD-1, PD-L1 and PD-L2 also have soluble forms aside from their membrane bound forms. The solubl...

journal_title：Cellular immunology

authors： Dai S,Jia R,Zhang X,Fang Q,Huang L

更新日期：2014-07-01 00:00:00

abstract：:The aim of this study was to clarify the role of IL-4, IL-10, IL-13 and interferon (IFN) -γ levels in atopic asthma patients by studying the relation between their serum levels and severity of the disease. The effect of IL-10 -1082G/A and IFN-γ +874T/A SNPs was also studied. The study included 200 atopic children with...

journal_title：Cellular immunology

authors： Hussein YM,Alzahrani SS,Alharthi AA,Ghonaim MM,Alhazmi AS,Eed EM,Shalaby SM

更新日期：2014-05-01 00:00:00

abstract：:Macrophages can be divided into two groups as M1 and M2 phenotype. Our results and other groups revealed that IFN-γ can up-regulate the IDO expression and differentiate THP-1 cells to M1 phenotype. Therefore we hypothesized that IDO may play potential roles in macrophage differentiation. Interesting, our results indic...

journal_title：Cellular immunology

authors： Wang XF,Wang HS,Wang H,Zhang F,Wang KF,Guo Q,Zhang G,Cai SH,Du J

更新日期：2014-05-01 00:00:00

abstract：:Type 2 diabetes is a chronic disease with growing public health concern globally. Finding remedies to assist this health issue requires recruiting appropriate animal model for experimental studies. This study was designated to evaluate metabolic and immunologic changes in streptozotocin-nicotinamide induced diabetic r...

journal_title：Cellular immunology

authors： Mojani MS,Sarmadi VH,Vellasamy S,Sandrasaigaran P,Rahmat A,Peng LS,Ramasamy R

更新日期：2014-05-01 00:00:00

abstract：:Dendritic cells (DCs) link the sensing of the environment by the innate immune system to the initiation of adaptive immune responses. Accordingly, DCs are considered to be a major target in the development of immunomodulating compounds. In this study, the effect of niclosamide, a Food and Drug Administration-approved ...

journal_title：Cellular immunology

authors： Wu CS,Li YR,Chen JJ,Chen YC,Chu CL,Pan IH,Wu YS,Lin CC

更新日期：2014-03-01 00:00:00

abstract：:The effect of programmed death 1 (PD-1) on cytomegalovirus (CMV)-specific T cells has not been thoroughly examined. We evaluated the involvement of exhausted CMV-specific T cells in persistent CMV infection after allogeneic hematopoietic stem cell transplantation (HSCT). CMV-specific CD8+ T cells obtained from an HLA-...

journal_title：Cellular immunology

authors： Kato T,Nishida T,Ito Y,Murase M,Murata M,Naoe T

更新日期：2014-03-01 00:00:00

abstract：:Recent evidence has shown that dietary phytosterols (PS) possess anti-inflammatory properties both in vivo and in vitro. Our previous work shows that PS β-Sitosterol (SIT), may function by down-regulating pro-inflammatory transcription factors NF-kB and STAT1 in response to LPS stimulation, possibly through modulation...

journal_title：Cellular immunology

authors： Valerio MS,Minderman H,Mace T,Awad AB

更新日期：2013-09-01 00:00:00

abstract：:Severe aplastic anemia (SAA) is a syndrome of severe bone marrow failure with high mortality. Our previous studies have demonstrated that both immature and activated DC1 increased in the bone marrow of SAA patients, and the balance of DC1 subsets shifted the stable form to active one, which might promote Th0 cells to ...

journal_title：Cellular immunology

authors： Liu C,Sheng W,Fu R,Wang H,Li L,Liu H,Shao Z

更新日期：2013-09-01 00:00:00

abstract：:Normal chondrocytes display susceptibility to lysis by natural killer (NK) cells and this phenomenon may play a role in some inflammatory cartilage disorders. The mechanisms of chondrocyte recognition and killing by NK cells remain unclear. Using flow cytometry and immunohistochemical staining we found that normal hum...

journal_title：Cellular immunology

authors： Białoszewska A,Baychelier F,Niderla-Bielińska J,Czop A,Debré P,Vieillard V,Kieda C,Malejczyk J

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:Piperine, a main component of Piper species, is a plant alkaloid with a long history of medical use in a variety of inflammatory disorders like rheumatoid arthritis. Due to side effects in current treatment modalities of rheumatoid arthritis, the interest in alternative, well tolerated anti-inflammatory reme...

journal_title：Cellular immunology

authors： Umar S,Golam Sarwar AH,Umar K,Ahmad N,Sajad M,Ahmad S,Katiyar CK,Khan HA

更新日期：2013-07-01 00:00:00

abstract：:Nickel (Ni) can cause delayed-type hypersensitivity reactions, which are thought to be mediated by the accumulation of T cells into inflamed skin. Accumulated T cells at the developmental stages in metal allergy are poorly characterized because a suitable animal model has not been established. To investigate the accum...

journal_title：Cellular immunology

authors： Eguchi T,Kumagai K,Kobayashi H,Shigematsu H,Kitaura K,Suzuki S,Horikawa T,Hamada Y,Ogasawara K,Suzuki R

更新日期：2013-07-01 00:00:00

abstract：:Viruses are related to the etiology of periodontitis. However, the role of viruses on Th17 cells infiltration in periodontitis lesions is unknown. Therefore, we examined the effects of TLR3 ligand on CCL20, which is related to Th17 cells migration, production in human gingival fibroblasts (HGFs). Polyinosinic-polycyti...

journal_title：Cellular immunology

authors： Hosokawa Y,Hosokawa I,Shindo S,Ozaki K,Matsuo T

更新日期：2013-05-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, played an important role in immune-mediated diseases. The promoter region of MIF, which had functional polymorphisms, controlled MIF expression. MIF polymorphism was associated with many inflammatory diseases. But the association of MIF polymor...

journal_title：Cellular immunology

authors： Zhang K,Pan X,Shu X,Cao H,Chen L,Zou Y,Deng H,Li G,Xu Q

更新日期：2013-04-01 00:00:00

abstract：:Semaphorins are important regulators of peripheral T and B-cell mediated immune responses in mice and humans. Modulatory roles of semaphorins in T cell development are also being characterized. We carefully analyzed the gene expression and protein levels of semaphorins 4A, 4D, and 7A at various developmental stages of...

journal_title：Cellular immunology

authors： Linder GE,Chuntova PD,McLelland BT,Añó L,Obodo UC,Crider NJ,Matthes DJ,García-Ojeda ME,Manilay JO,Chatterjea D

更新日期：2013-02-01 00:00:00

abstract：:Atherosclerosis involves immune mechanisms: T lymphocytes are found in atherosclerotic plaques, suggesting their activation during atherogenesis. The predominant voltage-gated potassium channel of T cells, Kv1.3 is a key regulator of the Ca(2+)-dependent activation pathway. In the present experiments we studied the pr...

journal_title：Cellular immunology

authors： Somodi S,Balajthy A,Szilágyi O,Pethő Z,Harangi M,Paragh G,Panyi G,Hajdu P

更新日期：2013-01-01 00:00:00

abstract：:The proapoptotic caspase adaptor protein (PACAP) is involved in cell-cycle regulation and promotes apoptosis. Both MGC29506 and PACAP are isoforms of the MGC29506 gene and are generated by differential splicing of the alternative splice-acceptor. In studying PACAP, we inadvertently constructed the eukaryotic expressio...

journal_title：Cellular immunology

authors： Xia L,Shen C,Fu Y,Tian L,Chen M

更新日期：2013-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been used to repair injured tissues through immune-suppression and/or cell replace mechanisms. However, a significant barrier to MSC therapy is insufficient MSC engraftment in injured tissues after systemic administration. Here, we report that cell surface, total protein, and mRNA le...

journal_title：Cellular immunology

authors： Xie J,Wang W,Si JW,Miao XY,Li JC,Wang YC,Wang ZR,Ma J,Zhao XC,Li Z,Yi H,Han H

更新日期：2013-01-01 00:00:00

abstract：:Although TGF-β and IL-6 would turn CD8(+) T cells to differentiate into non-cytotoxic state, these treated cells were converted to cytolytic phenotypes after re-exposure to their antigenic epitope in vitro. Here, using spleen cells from TCR transgenic mice expressing TCRαβ genes of clone RT1 recognizing an epitope pep...

journal_title：Cellular immunology

authors： Takaku S,Nakagawa Y,Owaki A,Shimizu M,Takahashi M,Takahashi H

更新日期：2012-12-01 00:00:00

abstract：:One of the auto-antigens aberrantly targeted in Multiple sclerosis is myelin basic protein (MBP). In this study, chronic progressive multiple sclerosis (CPMS) patients receiving the experimental drug MBP8298, on a compassionate care trial, were examined before and after high dose peptide treatment for their circulatin...

journal_title：Cellular immunology

authors： Loo EW,Krantz MJ,Agrawal B

更新日期：2012-11-01 00:00:00

abstract：:Caused mainly by Candida albicans, oropharyngeal candidiasis is the most common oral complication associated with HIV disease worldwide. Host defenses against C. albicans essentially fall into two categories: specific immune mechanisms and local oral mucosal epithelial cell defenses. Since oral mucosa is the first lin...

journal_title：Cellular immunology

authors： Rouabhia M,Semlali A,Audoy J,Chmielewski W

更新日期：2012-11-01 00:00:00

abstract：:American cutaneous leishmaniasis (ACL) is a disease where susceptibility or resistance is dependent on T cell response. This is characterized by an increased in CD4⁺ T cells, capable of inducing opposite disease profiles, and CD8⁺ T cells, that are related to immuno protection. We characterized T lymphocytes from pati...

journal_title：Cellular immunology

authors： Brelaz-de-Castro MC,de Almeida AF,de Oliveira AP,de Assis-Souza M,da Rocha LF,Pereira VR

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:We aim to evaluate the effects of atorvastatin on the expression of Toll-like receptor (TLR4) protein and mRNA, and to explore their effects on TLR4-dependent downstream signaling in human monocytic leukemia (THP-1) cells. METHODS:TLR4 protein and mRNA expression, levels of NF-κB protein, and expression of TNF...

journal_title：Cellular immunology

authors： Yang SS,Li R,Qu X,Fang W,Quan Z

更新日期：2012-09-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) play a major role in modulating immune response, but only a few reports focused on MDSCs in the liver of sepsis states. Here, we investigated the changes in MDSCs in liver of the cecal ligation and puncture (CLP) mice. The results of flow cytometry showed that MDSCs accumulate ...

journal_title：Cellular immunology

authors： Ren D,Bi Q,Li L,Gao Y,Liang Y,Li Y,Liu J,Peng L,Xiao J

更新日期：2012-09-01 00:00:00

abstract：:Anti-TNF-α therapies have been applied in RA treatment, but the regulatory effect of the drug on immune system is not clear. In this study, we included 33 active RA patients and divided them into two groups. One group received anti-TNF-α mAb+methotrexate for 24 weeks, the other group got placebo+methotrexate for the f...

journal_title：Cellular immunology

authors： Huang Z,Yang B,Shi Y,Cai B,Li Y,Feng W,Fu Y,Luo L,Wang L

更新日期：2012-09-01 00:00:00

abstract：:Cytokines are soluble proteins that mediate immune reactions and are responsible for communication among immune cells. CD4(+) T cells are the principle sources of cytokines of adaptive immunity. Cytokines play critical roles in the differentiation and effector function of CD4(+) T cells. They also play key roles in di...

journal_title：Cellular immunology

authors： Guo X,Zhang Y,Wang P,Li T,Fu W,Mo X,Shi T,Zhang Z,Chen Y,Ma D,Han W

更新日期：2012-07-01 00:00:00

abstract：:CD40 and its ligand (CD40L) regulate several cellular functions, including T and B-cell activation. The soluble form of CD40 (sCD40) antagonizes CD40/CD40L interaction. Patients undergoing hemodialysis (HD) present elevated sCD40 serum levels, which underlying molecular mechanisms are unknown. We studied sCD40 serum a...

journal_title：Cellular immunology

authors： Esposito P,Rampino T,Gregorini M,Gabanti E,Bianzina S,Dal Canton A

更新日期：2012-07-01 00:00:00

abstract：:Essential thrombocythemia (ET), polycythemia vera (PV) and myelofibrosis share the same acquired genetic lesion, JAK2V617F. It is believed that cytokines participate in the activation of JAK2V617F. In this study, we analyzed the plasma levels of interleukin (IL)-23, IL-10 and IL-22 in patients with PV and ET. In the s...

journal_title：Cellular immunology

authors： Gangemi S,Allegra A,Pace E,Alonci A,Ferraro M,Petrungaro A,Saitta S,Gerace D,Russo S,Penna G,Musolino C

更新日期：2012-07-01 00:00:00

abstract：:Chitin oligosaccharides (NA-COS) of two different molecular weight ranges (below 1 and 1-3 kDa) were examined for their capabilities against lipopolysaccharide-induced inflammatory responses in BV-2 murine microglia. It was found that NA-COS reduced the level of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) produc...

journal_title：Cellular immunology

authors： Vo TS,Ngo DH,Ta QV,Wijesekara I,Kong CS,Kim SK

更新日期：2012-05-01 00:00:00

abstract：:Four groups of colostrum-deprived pigs were immunized with Porcilis Glässer® (PG) or with subunit vaccines developed by us (rTbpA, NPAPT(M) or NPAPT(Cp)) against Glässer's disease, and they were challenged with 3×10(8)CFU of Haemophilus parasuis. A strong reduction in CD3(+)γδTCR(+) cells was seen in non-immunized con...

journal_title：Cellular immunology

authors： Frandoloso R,Martínez-Martínez S,Yubero S,Rodríguez-Ferri EF,Gutiérrez-Martín CB

更新日期：2012-05-01 00:00:00

abstract：:It has long been believed that mast cells play a crucial role in the development of many physiological changes during immediate allergic responses. This study was conducted to evaluate the anti-inflammation mechanism of Schizonepeta tenuifolia (ST) extract and ST purified chemicals on the PMA plus A23187-induced stimu...

journal_title：Cellular immunology

authors： Sohn SH,Cho S,Ji ES,Kim SH,Shin M,Hong M,Bae H

更新日期：2012-05-01 00:00:00

abstract：:Plasmacytoid dendritic cells (PDCs) from human umbilical cord blood (UCB) produce lower amounts of IFN-α upon TLR stimulation compared with adult counterparts. This difference may play a role in the low graft-versus-host disease rate after UCB transplantation and in the impaired immune response of the neonate to patho...

journal_title：Cellular immunology

authors： Charrier E,Cordeiro P,Cordeau M,Dardari R,Michaud A,Harnois M,Merindol N,Herblot S,Duval M

更新日期：2012-03-01 00:00:00

abstract：:We investigated the influence of Panagen DNA preparations on laboratory animals and IFN-induced human dendritic cells, as well as analyzed the data from a phase II clinical trial in the therapy of breast cancer. It was shown that this treatment resulted in increased number of CD8+/perforin+ T cells in peripheral lymph...

journal_title：Cellular immunology

authors： Alyamkina EA,Leplina OY,Ostanin AA,Chernykh ER,Nikolin VP,Popova NA,Proskurina AS,Gvozdeva TS,Dolgova EV,Orishchenko KE,Rogachev VA,Sidorov SV,Varaksin NA,Ryabicheva TG,Bogachev SS,Shurdov MA

更新日期：2012-03-01 00:00:00

abstract：:Within lymphopenic recipients, naïve T cells undergo proliferation that is induced by homeostatic mechanisms. Earlier studies have demonstrated that commensal antigens play a key role in inducing the proliferation. However, a relative contribution of endogenous self antigens in this process has not been formally inves...

journal_title：Cellular immunology

authors： Do JS,Foucras G,Kamada N,Schenk AF,Shaw M,Nuñez G,Paul WE,Min B

更新日期：2012-01-01 00:00:00